G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design. Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs. Essential reading for medicinal chemists and drug designers working with this largest class of drug targets in the human genome.

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знания и навыки

Ligand Design for G Protein-coupled Receptors

Early Drug Development

Combinatorial Chemistry

Molecular Biology in Medicinal Chemistry

Target Discovery and Validation

Neglected Tropical Diseases

Innovative Dosage Forms

Quantum Medicinal Chemistry

Molecular Interaction Fields

Полная версия:

Raimund Mannhold Ligand Design for G Protein-coupled Receptors

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