 
  


         ,   ,            .     ,          ,    .





 



  



  ,2023



ISBN978-5-0059-9541-4

     Ridero







 ,     . Ƞ    .



 ,         ,        .        ,             ,   ()       .                 .            ,       .                .

  ,   .      ,  ,   ,  ,   ,  ,    ,  ,   ..              .  ,       ,  ,          ,     ,         ,            .       .      ,        ,      .     .

       ,       .

     ,    .   ,              .     (),     ,       .  ,        ,         .       ,   ,  ,       . ʠ,     ()  ,   ,        ,   ,   ,    .    ,       ,  , ,  ,       faute de mieux,         ,     ,      .          ,     .                 .          ,     .

         ,    ,    ,  - ,   ,  ,   ,  .




 1. ,   





 1. ,     


       .

  

    ,    ,     ,  ,       ,     ,   ,         .      ,      ,       .

 ,  ,     ,    ,   .      ,   頖 . ʠ  :

:  ,  ,   ,  ;

:   , , , ;

:   ,   ,  -,    .;

 : , , , ;

:  ,   ,  ,    ;

:   , , ,  ,  ;

:    ,  , , ,  NK-,   ,     ,  BRCA1 BRCA2    , ARC     ..

:   ,  -,  ,  ,  ..

         , ,    ,      .   :

1.     .  ,       ( ),       .         .

2.  .      ,   .     ,   .        ,         (    ,  ),  .      ,    ,     .

3.   - .          ,        .   ,         ,         .         -    ,      .

4.  .         .     ,       ,     ,        .       ,  ,        .

5.   .   ,   , , . .   ,   .    ,      , , , -   . ,  , ,   ,   ,       .

6.  .          .    ,    .        ,  堖  ,   .

7. .           .       ,       ,   .      ,       (-2),    ,   ,    ,   ,    ,     ,   ,       .            ⠖    ,   , , -1, ,  ..  ,   ,    ( 1, 6, 8),        ,        .

8. .          ⠖     .                ,   .        ,     ,       .           ,  ,     ,    ,   -,   .

,      .      ,  ,       .       ,   .              ,     . ,     ,   ,   ,   , .

9.  .       :

   ;

   ;

     .

            .

   ,     .      :   ( )   .      ,       36  (),   ,  ,  .    ,        .   ,         ,    2     . ,          ,    .     ,   , .      80%       ,   1927. ,            ,     ,   ,  .

   ,   ,    ?       .    ,  ,           .

  ,    ,  ,     .                 .    ,  頖    , ,   , ꠖ   ,   ,  , .     ,  ࠫ        .

     :

     ;

  ,         ;

 ,         .

 ,       ,   ,    ,  ,    ,  ,     , ,      ( ). ,      ,          ( ,   ),   .

,             ,    . ,     ,       ,     ,      . ,   - ,    ,    ,     ,        .          . ,  ,  , 50%   ,    . Ѡ  30%     .               ,  ,    .     ,   , ,         (         ).

        ,   ,     .      ,               . ,     ,   ,   ,     .  ,      ,   ,     ,   : ,  .       ,       ,         ,   ,    .        ,  ,      ,   .    (  )     ,     ,    .         ,     (      ),   ,    .       ,   ?

1.  ,   ,    ,   ,   ..

2.      ,   ,   .

3.            .

4.     , ,  , ,     .

5.      .

6.               .

7.        .

 , ,   ,          ,           ,       .

   ?

1.   .

2.  ,   .

3.    .

4. .

5.  .

6.  .

7.    ,      .

8.   ,  , ,  .

9.     ,    .

10.    ,   ,  .

11.   , , ,  

12.  ,  ,  , .

13.   .

              .    ,  ,   ,  ,          . ,     , ,     .   ,   ,        ,   ,    ,   .     ,       ,   ,          . Ƞ       .

      ,     ,   .




 2.   


  , .

 

   , 堖  .



    ,    ,        ,       .   ,     ,   ,    ,   .              . -        -   ,       ,     ,   ,     ,     ,     ,    . ,         , , ,   ,       .              ,    .  ,         ,    - ,         .  ,      ,  ,      .   ,    ,   ,     .   30000,  2012 ,   ,        .    -  ,            .       .      -    .   ,         ? ʠ  :  , ,      ,   ,   .          .    ,      .

 ,      ,     ,   ,           ..        .  ,        ,    - ,     ,  蠖  -    ,  -           ,  .   ,        ,          .        ,   -   ࠖ  ,                HER2/neu.  ,          ,           (        ).  -    ,  ,       ,           ,       .   ,     ,   :       (      ,   ). , -          ,   :    .       ,        ,    .

  ,      ,        ,     ,         .    : , , ,     ,  ,  .. ,  ,  ,         .      ࠖ .         .          ,          .

      ,    ,      ,  ,      .       .     ()   (),         -, , ,   53,   ,    .  ,        ,    . ,       . ,          .

      MTHFR,      (MTHFR).  MTHFR    ( 9)    .      ,    ,     .    ,    20% ,   MTHFR,  50% ,      5070%,        . ,     :

       ;

     MTHFR.

    , , ,  ,   ,   .      ,   ,   ,    . ,  ,  ,             .

      MTHFR      ,     MTHFR,    ,       .

      6, 12  : , , . ,             . ,        ,    ,         . ,        .

  ,         ,     ,       .        ,    , - , .      MTHFR  ,   ,  ,            .    ,        ,     ,  , ,   6, 9, 12,        . ʠ,                .  ,           .

     ,       ,    200  . Ѡ          , ,        ,   ,   ,   ,        .        : , , .        ,      .  [1 - M.Lorenzi, D. F.Montisano, S. Toledo, A. Barrieux, High Glucose Induces DNA Damage inCultured Human Endothelial Cells, Journal ofClinical Investigation 77, no. 1(January 1986): 32225, doi:10.1172/JCI112295.] ,            .      ,      ,      .     ,       -6 ,  ,      -3 .     ,     ,   ,   ,       .

  ?       .    ⠖ ,   ,  ,    ,   [2 - Avinash M. Top? and Phyllis F. Rogers, Evaluation ofProtective Effects ofSulforaphane on DNA Damage Caused byExposure toLow Levels ofPesticide Mixture Using Comet Assay, Journal ofEnvironmental Science and Health, Part B 44, no. 7(September 4, 2009): 65762, doi:10.1080/03601230903163624.].   -,       ,     [3 - Yolanda Lorenzo, Aamia Azqueta, Luisa Luna, Flix Bonilla, Gemma Dominguez, and Andrew R. Collins, The Carotenoid ?-Cryptoxanthin Stimulates the Repair ofDNA Oxidation Damage inAddition toActing as an Antioxidant inHuman Cells, Carcinogenesis 30, no. 2(December 4, 2008): 30814, doi:10.1093/carcin/bgn270.].      ,   , , , ,  , ,    ,    .    .

  ,   ,        ʠ   ,   ,   ,    12 9.              ,      ,   ,           .    ,            ,       .  ,          .  ,                     ,  .

    ,  ,  .      80%      ,       .                  .           .   : , , ,            5[4 - Joseph E. Pizzorno and Michael T. Murray, Textbook ofNatural Medicine (St. Louis, MO: Churchill Livingstone Elsevier, 2006).].      ,    ,  , , ,     ,        ,    ,  ,  ,  ,      .  ,      [5 - Yasuhito Onodera, Jin-Min Nam, and Mina J. Bissell, Increased Sugar Uptake Promotes Oncogenesis via EPAC/RAP1 and O-GlcNAc Pathways, Journal ofClinical Investigation 124, no. 1(January 2, 2014): 36784, doi:10.1172/jci63146.]     53,     ,   . ,    ,  , 50 ,   .               . ,      3      . ,  ,         (),     ,   (   )      .    ,   ,             36   .       2    ࠖ  .        ,     100 ,     ,   , ,     ,  , .       , ,  ,  ..

       ,       ,            , , , , , , , ,  ..        , , , , , ,  ,  , , ,  , ,  ,  ,  , ,  ,  . ,   ,      ,     ,  , ,    ࠖ    ,   ,          .      ,          . ,              .




 3.  .  


,   ,   .

 

  ,    .   ,       ,   ,   . ,     ,  ,    ,   ,      ,         ,      ..       ,  ,  ,  . ʠ,         ,     , , ,  ,      (  ) ..       :  ,   .         ,    .

      ⠖  .    ,    .      , ,     .         .  ,      ,     ,  ,  , , , . ʠ  : ,  ,  .       ,     .       .

   20%  , 頖 10%,       70%, . .          .

       ?

   :

1.    ().      20,     3,4-.

2. ,  N-.     ,    .

3. ,   ,  ,  .       1, 2, G1, G2,      .    , , ,      .

4.   .       , ,  , , ,   ,          [6 - Maria E. Morales, Revecca S. Derbes, Catherine M. Ade, Jonathan C. Ortego, Jeremy Stark, Prescott L. Deininger, and Astrid M. Roy-Engel, Heavy Metal Exposure Influences Double Strand Break DNA Repair Outcomes, PLOS ONE 11, no. 3(March 11, 2016): e0151367, doi:10.1371/journal. pone.0151367.].

5.  , , .     .   ,  ,  -137,  젖 -90.  -90   ,      .     -131.

6.    ,   .

7.   ,   .

8.  .            ,    . ,        , 젖 ,     , ,    ,      [7 - Gary D. Friedman, Natalia Udaltsova, James Chan, Charles P. Quesenberry, and Laurel A. Habel, Screening Pharmaceuticals for Possible Carcinogenic Effects: Initial Positive Results for Drugs Not Previously Screened, Cancer Causes and Control 20, no. 10(December 2009): 182135, doi:10.1007/s10552-009-9375-2.] ..

  2012 Archives ofSurgery  ,      , , ,   .  , ,    ,   ,   [8 - John Neustadt and Steve R. Pieczenik, Medication-Induced Mitochondrial Damage and Disease, Molecular Nutrition and Food Research 52, no. 7(July 2008): 78088, doi:10.1002/mnfr.200700075.].

,           ,    .       .    .  , , ,  ,   . ,           5%,     ,  ,   .

      ,       [9 - ..  . .: , 2018, 479.],    ,         .

    ? , ,  , , ,           ,      .    ,      ,   ,     . ,         ,  ,          ,   ,    ,            .

    .  ࠖ ,  ࠖ ,  ࠖ .               , ,    ,       ,   .         ,    ,   ,    ,       ,      .

     , , ,       ,     .      50,   450.              .        , . .   ,     ,   .   450        : ,  2, 3, 6, 9, 12.       ,      ,   ,     .

       : , , ,  ,  , .         . ,   ,  ,   . .,    ,    ,     ,  ,  , , , ,       .         .          ,     ,    .

       ?    :  ,  , , ,  , , , ,  12.         , : , , , , ,  2,  .     .

 ,  ,       ,    ,      ,   ,     ,    .     堖    .        , ,  , ,  , ,   .      ,   , , .     ,    , .      ,    ,    ,  ,  ,     ࠖ    .     ,    ,       .    ,   ,  ,            .

        ,     .        .  ,        .       12,     .      .

        [10 - Vasil Georgiev Georgiev, Jost Weber, Eva-Maria Kneschke, Petko Nedyalkov Denev, Thomas Bley, and Atanas Ivanov Pavlov, Antioxidant Activity and Phenolic Content ofBetalain Extracts from Intact Plants and Hairy Root Cultures ofthe Red Beetroot Beta vulgaris cv. Detroit Dark Red,Plant Foods for Human Nutrition 65, no. 2(June 2010): 10511, doi:10.1007/s11130-010-0156-6.]    .            ..

,  ,      ,    .         , ,   .        ,   .         ,  , .

     ,  , ,   ,   .    ,    .

        .   100  3 ,    ,    ,  ,  50%[11 - Patricia A. Egner, Jin-Bing Wang, Yuan-Rong Zhu, Bau-Chu Zhang, Yan Wu, Qi-Nan].

       ,    . ,          .         .     ,      .    ,  .

     .        ,   .            ,   .  [12 - Stefania Miccadei, Donato Di Venere, Angela Cardinali, Ferdinando Romano, Alessandra Durazzo, Maria Stella Foddai, Rocco Fraioli, Sohrab Mobarhan, and Giuseppe Maiani, Antioxidative and Apoptotic Properties ofPolyphenolic Extracts from Edible Part ofArtichoke (Cynara scolymus L.) on Cultured Rat Hepatocytes and on Human Hepatoma Cells, Nutrition and Cancer 60, no. 2(March 2008): 27683, doi:10.1080/01635580801891583.] ,     ,   ,      .

 ,         .        ,    ,       .

Ѡ        .      ,    ,  ,    ,    ,    .     ,   -1,   ,     .       ,    .       .         . ,          ( 3) ,      .           ,    .

 ,           ,     ,    ..         ,   ,     . ,  ,   ,  , ,  ..      .          .




 4. 


   ,   .

 

  ,   .


,   ,     ,   .           .     , , , , ,  .     .

   750 ,  ,         2,5.        10%   ,   20%  [13 - ..  / ... 3- ., . . .: -, 2010. 366.].

             814%,  1518%   .

        . Ӡ      130% ,    .        ,         .         [14 - Stephenson GD, Rose DP. Breast cancer and obesity: an update. Nutr Cancer 2003;45:116.][15 - Stoll BA. Nutrition and breast cancer risk: can an effect via insulin resistance be demonstrated? Breast Cancer Res Treat 1996; 38: 23946.][16 - Bruning PF. Endogenous estrogens and breast cancer apossible relationship between body fat distribution and estrogen availability. J Steroid Biochem 1987; 27: 48792.].

 [17 - El-Serag HB, Hampel H, Javadi F. The association between diabetes and hepatocellular carcinoma: asystematic review ofepidemiologic evidence. Clin 4: 369380.] ,   ,  ,    ,     .        , ,   [18 - Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: areview. Am J Clin Nutr 2007;86: s83642.], . .     .                    .

  16-        [19 - Ildaphonse G, George PS, Mathew A., Obesity and kidney cancer risk inmen: ameta-analysis. Asian Pac J Cancer Prev. 2009Apr-Jun; 10(2): 27986.][20 - Bergstrom A1, Hsieh CC, Lindblad P, Lu CM, Cook NR, Wolk A. Obesity and renal cell cancer aquantitative review. Br J Cancer. 2001Sep 28;85(7):98490.],         .         ,          [21 - Otunctemur A, Ozbek E, Sahin S, Dursun M, Besiroglu H, Koklu I, Erkoc M, Danis E, Bozkurt M, GurbuzA. Diabetes mellitus as arisk factor for high grade renal cell carcinoma. Asian Pac J Cancer Prev. 2014: 15f9): 39936.].  -         ,   .   ,     ,   ,   .

,    40%       .         ,   ,  25.  ,        ,    .        .        ,   80%   .  20%  ,   ,          .

  ,             .        31%     [22 - Lahmann PH, Lissner L, Berglund G. Breast cancer risk inoverweight postmenopausal women, Cancer Epidemiol Biomarkers Prev 2004; 13:1414.]. ,   20%        .          .       15%,        40%[23 - Andersson SO, Wolk A, Bergstrom R, et al. Body size and prostate cancer: a20-year follow-up study among 135006Swedish construction workers. J Natl Cancer Inst 1997; 89-385-9.].            .               ,     .    ,          ,     .

 [24 - Stolzenberg-Solomon RZ, Adams K, Leitzmann M, et al. Adiposity, physical activity, and pancreatic cancer inthe National Institutes ofHealth AARP Diet and Health Cohort. Am J Epidemiol.2008; 167(5): 586597.][25 - Patel AV, Rodriguez C, Bernstein L, Chao A, Thun MJ, Calie EE. Obesity, recreational physical activity, and risk ofpancreatic cancer inalarge US cohort. Cancer Epidemiol Biomarkers Prev.2005; 14(2): 459466.][26 - Larsson SC, Orsini N, WoJk A. Body mass index and pancreatic cancer risk: ameta-analysis ofprospective studies. Int J Cancer. 2007; 120(9): 19931998.]         .      ,     [27 - Donghui Li, PhD; Jeffrey S. Morris, PhD; Jun Liu, MS; Manal M. Hassan, MD, PhD; R. Sue Day, PhD; Melissa L. Bondy, PhD; James L. Abbruzzese, MD. Body Mass Index and Risk, Age ofOnset, and Survival inPatients With Pancreatic Cancer. JAMA. 2009; 301(24): 25532562.]. ,   , ,      ,      ,         ,      ,   .

,   ,          ,       ,     , ,   ,    ,  ,     ,      .  ,  ,           ,      57%[28 - A. H.Eliassen et al., Adult Weight Change and Risk ofPostmenopausal Breast Cancer, JAMA 296, no. 2(July 12, 2006): 193201.].   atout prix[29 -   (.)]     .




 5.  


  ,  ,    .



      .       ,   , , ,  ,  ,   ..        .     ,  ,     .  , ,   ,      .          ,  ,      .          .    :    ,   ,   ,     ..

     ,     .  ,  ,   ,     ,       .   ,  ,  ,    .        .     ,  ,      .

 ,        : , , , , ,   , .  ,       .      -     40.       (   ),  (      ), ,  (       ),   ,       .     ,     , ,     ,    ..

          .    ,      .    - ,      ,     . ʠ  , , , , , , - , .     , , .              .       ,       ,     ,          .       - ,   -, , , ,   .

     ,    (, ,  ),   (, , ), ,    (), ,     ( ),   (, , ),     ( ) - .             .  ,       ,      ,           .   ,         .      (3)  (4),    .       ,      ()     ,   , ,  .    ,      .                 .        ,  ,  ,   ,   ,  .  ,         . , ,        .     ,    .      ,          .

      , . .    .     ,     .      ,     .

ʠ ,    ,  ,      , , ,   ,   ,  , ,  ,   ..ʠ    ,  ,   .      ,   .        .  ,  - .   ,     (   ),     (    ),   (   ).        ,     ,   , ,   (        ),   ,    ,  ,  , .    ,   ,   ,     .

          ,         .          -  ,      ,     ,  ,    .      ,    -  .       ,   .  ,        ,   ,   , , ,     .

    ࠖ   ,    , ,  ,      ,  ,  .  ,       ,     .     ,      ,      ,   ..

           .   ,        .           .       :

  ;

 ,  ,  ;

  ;

   ;

    ;

     ,  , , , - .

,   ,   ,   ,  ,    .        ,   :

   ;

     ( );

   .

       20,        .      , - ,   ,   . ʠ, ,             (-  ),   ,      ,   ,      .        (   ,   ),     .           .          ,   ,          ,     .  :  ,           ,   ,    , , ,     .

  ()     - (-).     ,   ,   ,     ,    ,   ,    ,    ,      ,   ,      ,  , ,   , , , .        ,   ,    ,     ,        . ,    ,       .     ,   ,   ,    .     :    , , ,  ,  . Ѡ,  ,     ,          .      ,        :          .  ,          707.       ,      ,        ,       .       ,   ?      :

   ;

   ,          ,   ;

 : , ,  ,       ;

   ,     ;

   ,     .

     ࠖ   -1(-1). -1      ,   , . .       .  ,          .         ,   -1,     .    -1,      ,    .   -1   ,       ,  ,  ,  ,         .     ,           -1(  ,   )  .

  ,   ,   ().   ,           .         ,     -6  -,    .      , , , .     ,    ,  ,   ,    .          -  .    ,  .      , 70  7080%.   ,         ,   . ,  2010, ,       . ,        ,   155%   - .       ,   ,   .  ,     ,    .

       ,     D3    ,     .   ,         : ,    .        ,   ,   ,    ,    .      ,    , ,  ,   .           ,   ,  ,   , .       .  ,   Mayo Clinic 2006  , ,       ,  ,  ,  .        ,        (  )   .  ,       (    )   , ,  ( ),        ,     510    1525  .

   ,            .      .      ,  ,    ,    .      ,   .    .    ,  ,      ,  ,   ,      ,  ,    : , , , ,  ,  ,     ,      .      02     . Ѡ    , 60     50%   20,      .       ,  ,  ,    ,  .   , ,     .          .    .      ,   .

    . :   ,             1,52  ,     .  ,               .  .   ,  ,    ,     ,     ,       .          . Ѡ    .     ,        ,    ,          .            1,53   .  ,       ,   ,          .

      , , , , , ,  ,   - - ,   ,  , ,  ,    .           ,    -  (  -).    7580%  - . ,    ,  - ,   ,    . ,          . (,   ,      -         .)

      ,   .      .    ,   ,      ,     , ,     ,  ,  ,   .       ,    ,  .          ,    , ,   ,     .        ,     .        .  ,     ,     .         ,          . , ,     ,     ,  ,  ,   , ,    .

     ?

1.  .        ,    .

2.       .

3.      ,  ,      .

4.   ,       .

5.       ,   (,  ,   ,  ),  (, , , , , ,  ),  (, , ),    ( , , , , , , , , ).

   ⠖   .  ,          .                .         ,    .  ,       ,   , ,    ,   ..     .

ʠ   : , , .     ():   ,   ,    ,  ,     ,  ,  - ,      ,   ,   ,      ,      ,        ,   ,    ..

       1520%,   , , . Ӡ      ,  ,  , ,  , .   1520%   ,    , , ,     .     ?

1.   ( 78).

2.   ( 3 ).

3.    ( ,    ).

4.   (   D    ).

5.   (      ).

6.     (   ,    ).

       ,  , ,  ,   ,  ,    ,  ,  ,    ,  ,  ..

 ,   (       ),  (  ,     ,     ),  (  2 L-        ),  (   , . .      ), -   (,  ,  , ),   (, , , ).

   (    ),    (   ,    ,       ),  (, ,   ;   ; ,    ,   ,  ).

    (,  ,  ), , ,  (      ,  ,     , . .       ), , , ,   (   ).

    ( Ѡ   ,     ,   ,     ,     ).

       ࠖ  .      ,   : , , , , , .     -1.    ,          ,     .

    .    .   ,    .     .          . Ӡ    .    :   ,     ,   ,       ,        ,     ,    ,   ,   ,  ,  ,   ,   ,    ,   ,       ,   , ,  ..   ,    .      ,   ,    .  ,  ,   ,    .       ,  ,   ,   ,  , ,     .     ?            . ,          ,  ,     ,        ,       . ,     :

1.   ,   (   - ), , ,   .

2.    (     ).

3.   (    ),   (  ),  ( ,   ),  ( ,     ),  (  ,    ),   (, ,     ;     ,   ; , , , ,     ).

4.  ,  , , .

5.       (       (     ,   ).

6.  ,  (   ,        ).

7.    (, , ,  ,   ,  ).

8.        (  ).

9.  , , ,   (  ).

10.    (DIM)  (chrystin),        41%.

11.   ,   , ,  (   ).

12.  , ,   (     ,      ).

13.  ,  ( ,     ).

14.   ,     ,   .

-    .   ,   ,     ER,  -    .            ,    ,   . ,       ,       ,            .            .   ,    ,      ,     ,          ,   .

,      ,  , ,    ,  ,        50% .  1999       ,        [30 - Rene Johnson, The US-EU Beef Hormone Dispute, Congressional Research Service, January 14, 2015, https://fas.org/sgp/crs/row/R40449.pdf.].

               , ,        .  ,         ,    .

 ,   ,   ,   ,        ,                 .




 6.  


     ,    .

 

       , , : - ,  , , ,   .        .        ,  ,     . ʠ,         -6,    -3.      -6-3  1:1,      20:1.         -2(-2),   .     ,  ,  ,  ,   .    ,   -6 ,      .         ,      ,    .    ,        .       ,        -6- ࠖ   .   , -6-        [31 - Jian-Hua Yi, Dong Wang, Zhi-Yong Li, Jun Hu, Xiao-Feng Niu, and Xiao-Lin Liu, C-Reactive Protein as aPrognostic Factor for Human Osteosarcoma: AMeta-Analysis and Literature Review, PLOS ONE 9, no. 5(May 6, 2014): doi:10.1371/journal. pone.0094632.].     ,     ,   .   .     ,     ()    .      , . .       ,     .   ,      .          ,           .

          , , ,    蠖 , , , ,   . ,      ࠖ  ,     , ,   ,        .

    ,  , ,   ,         .    , , , ,  ,  ,  , , , ,  , ,  ,   ,  ,  ..

,  ,   ,   ? ,  .  ,  , , , , , , , , , .       : , , , ,  ( ), , , .     ( , , , , ),   ( ,  , , ,    ).     ,    Q


,         ,     .

 [32 - ..  . .: , 2018, 479.] ,  - ,    ,             - ,    .

   ,   ,      .          80% .      ,    [33 - Jill K. Onesti and Denis C. Guttridge, Inflammation Based Regulation ofCancer Cachexia, BioMed Research International 2014(May 4, 2014): 17, doi:10.1155/2014/168407.].    ,    ,      .           . ,       ,           ,    .   ? -, ,         ,       -,    ,    ,                 .        , ,   [34 - Surendra K. Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V. Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, et al., Metabolic Reprogramming Induced byKetone Bodies Diminishes Pancreatic Cancer Cachexia, Cancer and Metabolism 2, no. 1(September 1, 2014): 18, doi:10.1186/2049-3002-2-18.],  ,  ,     .       ? , .      , -    . ,  ,        ,        .  ,        ,    ,    .

  ,            .    ,           ,    .     ,     ,   ,    . Ѡ ,        10000 ,          ,        .        , , , .

      ,          .  ,              .    ,               ,  , .     ,      .

 ,   450         . ,        .   ,     90%   ,    ,    .             , , ,               .         .          ,  , ,      ,   ,       .

       , , , , , ,   ..

 ,      ,        .    ,     ,  .

    ?      ,    ,     .      ,  .

Ѡ          .     ,     . ʠ  :

 ();

;

;

;

 .

   .    ,  -   ,  ࠖ  ,    .    ,    .   ,    ,    .           , ,       ,     ,         . ,     ,     ,  -    .         .         ,   ,         .

      ,     .        .         (    NADP).         ,    ,      .           .         .  ,   Ѡ   ,  .       .  ,         .              ,     ,  .      .     ,    , , ,  ,  .        : , , .      ,      ,    .   .        ,  .    ,  - .   ,       10%      .

 ,            .

          ,   . ʠ  ,  (,  ), , ,     ,         ,      .

         ,        .      ,          ,          .           .          ,         .          (-),  , - , , , , .        ⠖    ,        .        ,  .       -,       ,      ,       .       (-)    .     Q10, ,  Ѡ  .    -,    .   ,     .       ,   ,   .        .   ,          ,   ( Q),      ,  -  -.      ,   ,             .      ,  ,  ,  .     ,  , . .    .   Q   , ,     .     ,         .        .     ࠖ        .

  ,   ,     , ,      ,       . Ƞ      ,   .    , 6, , ,  , SH- .           Ѡ .  Ѡ      . ,     SH-,    .     ,   Ѡ ,  ,   ,         . ,  Ѡ,   ,      .       ,     .    , ,    -. ,  ,   -,     ,    .     ⠖   ,  , .

       .          ,    , , ,  ..  , ,  ,   ,   .

 ,       ,  ,        .   ,           (, ,   )   .    .      ,         ,   ,      ,   ,   .  ,               .                 - ,       .        .             ORAC (oxygen radical absorbency capacity).        .    6000 ORAC .   ,     [35 -  ,   100%. .: , 2012. 400.],     2000.        6000 ORAC.

,    ,       ,     . , , , ,      ⠖ .  -    ,  , ,  ..      ,    蠖   ,    .

,     ORAC   (    50,   . .)       .       :

- (- ) 7;

  (d-- ) 100;

 Ѡ 10001500;

 Q10 10 ( 90,    );

- ࠖ 10;

 50;

L- ( ) 50;

렖 20.

        (3000)  ,  -,  Ѡ(15002000),   (100)  (30100),    B,  .           ,      ,             .       ,  , 8--2-,     ,  ,   (    ),      (       ,     ),    .     -   .  ,   ,   ,       ,            .   ,      ,   ,       .

 [36 - Hu Wang, Tin Khor, Limin Shu, Zheng-Yuan Su, Francisco F. Fuentes, Jong Hun Lee, and Ah-Ng Tony Kong, Plants vs. Cancer: AReview on Natural Phytochemicals inPreventing and Treating Cancers and Their Druggability, Anti-Cancer Agents inMedicinal Chemistry 12, no. 10(May 2012): 1281305, doi:10.2174/187152012803833026.] ,        ,  . ,   :  ,    ,    ,  ,  ,  ,   .

      ,          .       . ,   ,    ,   .     [37 - ..      /  . [. .]:  , 2021. 306.].




 7.   


   .



   .


       .      : ,  .    ,    ,    ,   , . .    .      ,      .       ,  ,   , ,     .     ,      ,     , ,  ,  ..    ,   , , ,  ..,     .        ,    .   .      ,    ,   ,      .           ,   ,        , ,  ,    .  ,    ,     , ,   ,       ,    ,             .    ,      ,       . ,                   .     .  ,       .        ,   ,       ,   .

        ,         [38 - Bo Christensen, Melatonin Could Be an Overlooked Treatment for Cancer, ScienceNordic, June 1, 2015, http://sciencenordic.com/melatonincould-be-overlooked-treatment-cancer.].        ,     , ,   .      ,     ,  ,   ,      . ,      ,     ,   .    , , , ,          .     (),     ,     ,    ,   [39 - Sheldon Cohen, Denise Janicki-Deverts, William J. Doyle, Gregory E. Miller, Ellen Frank, Bruce S. Rabin, and Ronald B. Turner, Chronic Stress, Glucocorticoid Receptor Resistance, Inflammation, and Disease Risk, Proceedings ofthe National Academy ofScience ofthe United States ofAmerica 109, no. 16(April 17, 2012): 599599, doi:10.1073/pnas.1118355109.]




  .


   .

   ,     (https://www.litres.ru/book/aleksandr-grigorevich-movsesyan/zhivuchest-bioorganizmov-69246622/)  .

      Visa, MasterCard, Maestro,    ,   ,     ,  PayPal, WebMoney, ., QIWI ,       .



notes








1


M.Lorenzi, D. F.Montisano, S. Toledo, A. Barrieux, High Glucose Induces DNA Damage inCultured Human Endothelial Cells, Journal ofClinical Investigation 77, no. 1(January 1986): 32225, doi:10.1172/JCI112295.




2


Avinash M. Top? and Phyllis F. Rogers, Evaluation ofProtective Effects ofSulforaphane on DNA Damage Caused byExposure toLow Levels ofPesticide Mixture Using Comet Assay, Journal ofEnvironmental Science and Health, Part B 44, no. 7(September 4, 2009): 65762, doi:10.1080/03601230903163624.




3


Yolanda Lorenzo, Aamia Azqueta, Luisa Luna, Flix Bonilla, Gemma Dominguez, and Andrew R. Collins, The Carotenoid ?-Cryptoxanthin Stimulates the Repair ofDNA Oxidation Damage inAddition toActing as an Antioxidant inHuman Cells, Carcinogenesis 30, no. 2(December 4, 2008): 30814, doi:10.1093/carcin/bgn270.




4


Joseph E. Pizzorno and Michael T. Murray, Textbook ofNatural Medicine (St. Louis, MO: Churchill Livingstone Elsevier, 2006).




5


Yasuhito Onodera, Jin-Min Nam, and Mina J. Bissell, Increased Sugar Uptake Promotes Oncogenesis via EPAC/RAP1 and O-GlcNAc Pathways, Journal ofClinical Investigation 124, no. 1(January 2, 2014): 36784, doi:10.1172/jci63146.




6


Maria E. Morales, Revecca S. Derbes, Catherine M. Ade, Jonathan C. Ortego, Jeremy Stark, Prescott L. Deininger, and Astrid M. Roy-Engel, Heavy Metal Exposure Influences Double Strand Break DNA Repair Outcomes, PLOS ONE 11, no. 3(March 11, 2016): e0151367, doi:10.1371/journal. pone.0151367.




7


Gary D. Friedman, Natalia Udaltsova, James Chan, Charles P. Quesenberry, and Laurel A. Habel, Screening Pharmaceuticals for Possible Carcinogenic Effects: Initial Positive Results for Drugs Not Previously Screened, Cancer Causes and Control 20, no. 10(December 2009): 182135, doi:10.1007/s10552-009-9375-2.




8


John Neustadt and Steve R. Pieczenik, Medication-Induced Mitochondrial Damage and Disease, Molecular Nutrition and Food Research 52, no. 7(July 2008): 78088, doi:10.1002/mnfr.200700075.




9


..  . .: , 2018, 479.




10


Vasil Georgiev Georgiev, Jost Weber, Eva-Maria Kneschke, Petko Nedyalkov Denev, Thomas Bley, and Atanas Ivanov Pavlov, Antioxidant Activity and Phenolic Content ofBetalain Extracts from Intact Plants and Hairy Root Cultures ofthe Red Beetroot Beta vulgaris cv. Detroit Dark Red,Plant Foods for Human Nutrition 65, no. 2(June 2010): 10511, doi:10.1007/s11130-010-0156-6.




11


Patricia A. Egner, Jin-Bing Wang, Yuan-Rong Zhu, Bau-Chu Zhang, Yan Wu, Qi-Nan




12


Stefania Miccadei, Donato Di Venere, Angela Cardinali, Ferdinando Romano, Alessandra Durazzo, Maria Stella Foddai, Rocco Fraioli, Sohrab Mobarhan, and Giuseppe Maiani, Antioxidative and Apoptotic Properties ofPolyphenolic Extracts from Edible Part ofArtichoke (Cynara scolymus L.) on Cultured Rat Hepatocytes and on Human Hepatoma Cells, Nutrition and Cancer 60, no. 2(March 2008): 27683, doi:10.1080/01635580801891583.




13


..  / ... 3- ., . . .: -, 2010. 366.




14


Stephenson GD, Rose DP. Breast cancer and obesity: an update. Nutr Cancer 2003;45:116.




15


Stoll BA. Nutrition and breast cancer risk: can an effect via insulin resistance be demonstrated? Breast Cancer Res Treat 1996; 38: 23946.




16


Bruning PF. Endogenous estrogens and breast cancer apossible relationship between body fat distribution and estrogen availability. J Steroid Biochem 1987; 27: 48792.




17


El-Serag HB, Hampel H, Javadi F. The association between diabetes and hepatocellular carcinoma: asystematic review ofepidemiologic evidence. Clin 4: 369380.




18


Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: areview. Am J Clin Nutr 2007;86: s83642.




19


Ildaphonse G, George PS, Mathew A., Obesity and kidney cancer risk inmen: ameta-analysis. Asian Pac J Cancer Prev. 2009Apr-Jun; 10(2): 27986.




20


Bergstrom A1, Hsieh CC, Lindblad P, Lu CM, Cook NR, Wolk A. Obesity and renal cell cancer aquantitative review. Br J Cancer. 2001Sep 28;85(7):98490.




21


Otunctemur A, Ozbek E, Sahin S, Dursun M, Besiroglu H, Koklu I, Erkoc M, Danis E, Bozkurt M, GurbuzA. Diabetes mellitus as arisk factor for high grade renal cell carcinoma. Asian Pac J Cancer Prev. 2014: 15f9): 39936.




22


Lahmann PH, Lissner L, Berglund G. Breast cancer risk inoverweight postmenopausal women, Cancer Epidemiol Biomarkers Prev 2004; 13:1414.




23


Andersson SO, Wolk A, Bergstrom R, et al. Body size and prostate cancer: a20-year follow-up study among 135006Swedish construction workers. J Natl Cancer Inst 1997; 89-385-9.




24


Stolzenberg-Solomon RZ, Adams K, Leitzmann M, et al. Adiposity, physical activity, and pancreatic cancer inthe National Institutes ofHealth AARP Diet and Health Cohort. Am J Epidemiol.2008; 167(5): 586597.




25


Patel AV, Rodriguez C, Bernstein L, Chao A, Thun MJ, Calie EE. Obesity, recreational physical activity, and risk ofpancreatic cancer inalarge US cohort. Cancer Epidemiol Biomarkers Prev.2005; 14(2): 459466.




26


Larsson SC, Orsini N, WoJk A. Body mass index and pancreatic cancer risk: ameta-analysis ofprospective studies. Int J Cancer. 2007; 120(9): 19931998.




27


Donghui Li, PhD; Jeffrey S. Morris, PhD; Jun Liu, MS; Manal M. Hassan, MD, PhD; R. Sue Day, PhD; Melissa L. Bondy, PhD; James L. Abbruzzese, MD. Body Mass Index and Risk, Age ofOnset, and Survival inPatients With Pancreatic Cancer. JAMA. 2009; 301(24): 25532562.




28


A. H.Eliassen et al., Adult Weight Change and Risk ofPostmenopausal Breast Cancer, JAMA 296, no. 2(July 12, 2006): 193201.




29


  (.)




30


Rene Johnson, The US-EU Beef Hormone Dispute, Congressional Research Service, January 14, 2015, https://fas.org/sgp/crs/row/R40449.pdf.




31


Jian-Hua Yi, Dong Wang, Zhi-Yong Li, Jun Hu, Xiao-Feng Niu, and Xiao-Lin Liu, C-Reactive Protein as aPrognostic Factor for Human Osteosarcoma: AMeta-Analysis and Literature Review, PLOS ONE 9, no. 5(May 6, 2014): doi:10.1371/journal. pone.0094632.




32


..  . .: , 2018, 479.




33


Jill K. Onesti and Denis C. Guttridge, Inflammation Based Regulation ofCancer Cachexia, BioMed Research International 2014(May 4, 2014): 17, doi:10.1155/2014/168407.




34


Surendra K. Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V. Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, et al., Metabolic Reprogramming Induced byKetone Bodies Diminishes Pancreatic Cancer Cachexia, Cancer and Metabolism 2, no. 1(September 1, 2014): 18, doi:10.1186/2049-3002-2-18.




35


 ,   100%. .: , 2012. 400.




36


Hu Wang, Tin Khor, Limin Shu, Zheng-Yuan Su, Francisco F. Fuentes, Jong Hun Lee, and Ah-Ng Tony Kong, Plants vs. Cancer: AReview on Natural Phytochemicals inPreventing and Treating Cancers and Their Druggability, Anti-Cancer Agents inMedicinal Chemistry 12, no. 10(May 2012): 1281305, doi:10.2174/187152012803833026.




37


..      /  . [. .]:  , 2021. 306.




38


Bo Christensen, Melatonin Could Be an Overlooked Treatment for Cancer, ScienceNordic, June 1, 2015, http://sciencenordic.com/melatonincould-be-overlooked-treatment-cancer.




39


Sheldon Cohen, Denise Janicki-Deverts, William J. Doyle, Gregory E. Miller, Ellen Frank, Bruce S. Rabin, and Ronald B. Turner, Chronic Stress, Glucocorticoid Receptor Resistance, Inflammation, and Disease Risk, Proceedings ofthe National Academy ofScience ofthe United States ofAmerica 109, no. 16(April 17, 2012): 599599, doi:10.1073/pnas.1118355109.


